Antihistamines are drugs which treat allergic rhinitis and other allergies. H₁ antagonists, also called H₁ blockers, are a class of medications that block the action of histamine at the H₁ receptor, helping to relieve allergic reactions. desloratadine, diphenhydramine, doxylamine, hydroxyzine, promethazine, phenyltoloxamine, orphenadrine, tripelennamine,
H1 antagonists/inverse agonists
- Acrivastine
- Azelastine
- Bilastine
- Bromodiphenhydramine
- Brompheniramine
- Buclizine
- Carbinoxamine
- Cetirizine (Zyrtec)
- Chlorodiphenhydramine
- Chlorpheniramine
- Chlorpromazine (antipsychotic, also used as an antiemetic)
- Clemastine
- Cyclizine
- Cyproheptadine
- Desloratadine
- Dexbrompheniramine
- Dexchlorpheniramine
- Dimenhydrinate (most commonly used as an antiemetic)
- Dimetindene
- Diphenhydramine (Benadryl)
- Doxylamine (most commonly used as an over-the-counter drug sedative)
- Ebastine
- Embramine
- Fexofenadine (Allegra/Telfast)
- Hydroxyzine (Vistaril)
- Levocabastine (Livostin/Livocab)
- Levocetirizine (Xyzal)
- Loratadine (Claritin)
- Meclizine (most commonly used as an antiemetic)
- Mirtazapine (primarily used to treat depression, also has antiemetic and appetite-stimulating effects)
- Olopatadine (used locally)
- Orphenadrine (a close relative of diphenhydramine used mainly as a skeletal muscle relaxant and anti-Parkinsons agent)
- Phenindamine
- Pheniramine
- Phenyltoloxamine
- Promethazine
- Pyrilamine (crosses the blood–brain barrier; produces drowsiness)
- Quetiapine (antipsychotic; trade name Seroquel)
- Rupatadine (Alergoliber)
- Trazodone (SARI antidepressant/anxiolytic/hypnotic with mild H1 blockade action)
- Tripelennamine
- Triprolidine